Therapeutic anti-tumor immunity triggered by injections of immunostimulating single-stranded RNA
نویسندگان
چکیده
منابع مشابه
Induction and characterization of anti-tumor endothelium immunity elicited by ValloVax therapeutic cancer vaccine
ValloVax is a placental endothelium derived vaccine which induces tissue-nonspecific antitumor immunity by blocking tumor angiogesis. To elucidate mechanisms of action, we showed that production of ValloVax, which involves treating placental endothelial cells with IFN-gamma, results in upregulation of HLA and costimulatory molecules. It was shown that in mixed lymphocyte reaction, ValloVax indu...
متن کاملSite size of cooperative single-stranded RNA binding by poliovirus RNA-dependent RNA polymerase.
The poliovirus RNA-dependent RNA polymerase binds cooperatively to single-stranded RNA. We have determined the minimal RNA-binding site size of the poliovirus polymerase using binding titration with oligonucleotides of increasing length. A dramatic increase in affinity was observed when the length of the oligo(U) increased from 8 to 10 nucleotides (nt), arguing that the minimal size of RNA for ...
متن کاملEnzymatic aminoacylation of single-stranded RNA with an RNA cofactor.
A chemically synthesized single-stranded ribonucleotide tridecamer derived from the 3' end of Escherichia coli alanine tRNA can be charged with alanine in the presence of short complementary RNA oligonucleotides that form duplexes with the 3' fragment. Complementary 5' oligomers of 9, 8, 6, and 4 nucleotides all confer charging of the 3' fragment. Furthermore, in the presence of limiting 5' oli...
متن کاملSingle-stranded DNA and RNA origami.
Self-folding of an information-carrying polymer into a defined structure is foundational to biology and offers attractive potential as a synthetic strategy. Although multicomponent self-assembly has produced complex synthetic nanostructures, unimolecular folding has seen limited progress. We describe a framework to design and synthesize a single DNA or RNA strand to self-fold into a complex yet...
متن کاملAuto-immunity as Evolutionary by Product of Adoptive Immunity and Source of Anti-tumor Immunity Failure
One of the biggest threats to survival is infection, so that the immune system is under permanent and strong evolutionary pressure to be highly responsive. By tracing the evolution of the invertebrate LPPXQH V\VWHP LW FDQ EH VHHQ WKDW LW ODUJHO\ IROORZHG WKH 3FODVVLFDO ́ PRGHO EDVHG RQ EL-directional 3SUHGDWRU-SUH\ ́ UHODWLRQVKLSV 6LPLODUO\ WKH HYROXWLRQDU\ HPHUJHQFH RI 0+& V\VWHP DQG WKH PHFKDQL...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: European Journal of Immunology
سال: 2006
ISSN: 0014-2980,1521-4141
DOI: 10.1002/eji.200635910